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Tapering Semaglutide: Evidence-Based Discontinuation Strategy – PlexusDx

5.4 Hypoglycemia Adult patients with type 2 diabetes mellitus on an insulin secretagogue (e.g., sulfonylurea) or insulin may have an increased risk of hypoglycemia with use of SAXENDA, including severe hypoglycemia

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Semaglutide is the most extensively studied GLP-1 receptor agonist — a single, highly selective incretin-pathway agonist that has become the reference standard against which newer dual and triple agonists are measured